Effects Of Lead On Reproductive System
Effects Of Lead On Reproductive Health Intechopen
Effects of lead on reproductive system. Exposure to lead may affect libido semen quality by declining sperm count motility viability integrity elevation in morphological abnormalities and sperm DNA integrity. The effects of lead on the male rat reproductive system. From the perspective of human reproduction lead is known to cause a number of adverse outcomes in both men and women.
Findings of this study suggest lead-induced pathophysiological alterations in myometrium which in turn may affect the reproductive efficiency of animals. In Anatomy Department of Anatomy School of Medicine Tehran University of Medical Sciences Tehran Iran. Lead concentrations were determined in plasma with inductively coupled plasma mass spectrometry ie index of recent exposure in blood.
Lead acetate was administered to male rats for 9 weeks in doses of 03 33 or 300 mgkg daily by gavage. Lead poisoning in the reproductive sistem disorders that can arise are decreased fertility in men and women increased miscarriage stillbirth premature birth and increased sex desire Skip to main content Skip to main navigation menu Skip to site footer. Reported effects in men include reduced libido effects on spermatogenesis reduced motility and numbers increased normal morphology chromosomal damage infertility abnormal prostatic function and changes in serum testosterone.
Lead may adversely impact sexual maturation in the developing female and may reduce fertility. Lead effects were measured on reproductive physiology and endocrinology sexually dimorphic hepatic testosterone hydroxylation and growth rates in both male and female animals. Similarly lead accumulates in granulosa cells of the ovary causing delays in growth and pubertal development and reduced fertility in females.
Although studies are limited there is some suggestion that blood lead at relatively low levels may lead to alterations in onset of sexual maturation Wu et al 2003 and reduced fertility Guerra-Tamayo et. The low lead dose significantly reduced the number of sperm within the epididymis while the high dose reduced both the sperm count and percentage of motile sperm and increased the percentage of abnormal sperm within. While several studies have implicated lead as contributing to reproductive and developmental effects these effects have not been well-established at low exposure levels.
This overview is based on the information of toxic potential of lead to human reproduction and reproductive outcome. High daily intake of AA from rich sources or from supplementation can protect reproductive system of male rats from lead toxicity. Lead can damage a developing babys nervous system.
Male Reproductive Effects Recent reproductive function studies in humans suggest that current occupational exposures may decrease sperm count totals and increase abnormal sperm frequencies NTP 2012. Adverse effects like altered spermatogenesis increased sperm pathologies and testicular degeneration due to lead have been studied well in males however studies on female reproductive toxicology are very less and differ from males due to differences in gametogenesis access of the germinal cells and also because of the revolving nature of female breeding function23 Severe cases.
Effects Of Lead On Reproductive Health Intechopen
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Similarly lead accumulates in granulosa cells of the ovary causing delays in growth and pubertal development and reduced fertility in females.
The reproductive system of both males and females is affected by lead. Lead concentrations were determined in plasma with inductively coupled plasma mass spectrometry ie index of recent exposure in blood. Exposure to lead may affect libido semen quality by declining sperm count motility viability integrity elevation in morphological abnormalities and sperm DNA integrity. Thus according to wide spectrum effects of lead at different concentrations on reproductive hormones and the priority of hormones for growth development and function of the sex organs and spermatogenesis the present review suggests that leads effects the male reproductive system most likely by disrupting hormonal regulations mostly via the HPT axis then reduces sperm. Adverse effects like altered spermatogenesis increased sperm pathologies and testicular degeneration due to lead have been studied well in males however studies on female reproductive toxicology are very less and differ from males due to differences in gametogenesis access of the germinal cells and also because of the revolving nature of female breeding function23 Severe cases. Reported effects in men include reduced libido effects on spermatogenesis reduced motility and numbers increased normal morphology chromosomal damage infertility abnormal prostatic function and changes in serum testosterone. Activities like motility and the general morphology of sperm are also affected at this level Navas-Acien et al 2007. High daily intake of AA from rich sources or from supplementation can protect reproductive system of male rats from lead toxicity. From the perspective of human reproduction lead is known to cause a number of adverse outcomes in both men and women.
In Anatomy Department of Anatomy School of Medicine Tehran University of Medical Sciences Tehran Iran. Lead poisoning in the reproductive sistem disorders that can arise are decreased fertility in men and women increased miscarriage stillbirth premature birth and increased sex desire Skip to main content Skip to main navigation menu Skip to site footer. Lead exposure can cause miscarriage stillbirths and infertility in both men and women. In Anatomy Department of Anatomy School of Medicine Tehran University of Medical Sciences Tehran Iran. Lead toxicity to the male reproductive system of sexually mature male CF-1 mice was investigated by administering two concentrations of lead 025 and 05 via drinking water for 6 wk. Similarly lead accumulates in granulosa cells of the ovary causing delays in growth and pubertal development and reduced fertility in females. In males sperm count is reduced and other changes occur in the volume of sperm when blood lead levels exceed 40 μgdL.
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